Acetaminophen Rises Systolic Blood Pressure in Those with Hypertension

Clinical question: Does regular intake of acetaminophen cause an increase in blood pressure? Background: Acetaminophen is one of the most commonly used analgesics in the world. Because of its widespread use and limited demonstrated efficacy, there have been growing reservations regarding its long-term safety, particularly its influence on blood pressure (BP). Study design: Single-center, randomized, double-blinded, placebo-controlled crossover trial Setting: United Kingdom Synopsis: 110 patients were randomized to receive 1 g of acetaminophen four times… ... read more